1. Core intermediate of pharmaceutical synthesis
As a key raw material of OZANIMOD, it can significantly improve the synthesis efficiency of multiple sclerosis drugs. It is used to synthesize 2-amino-6-bromoindenopyridine derivatives. The microwave assisted method shortens the reaction time by 60% and improves the yield to 85%.
2. Alzheimer's disease drug development:
As precursor of donepezil hydrochloride analog, its indanone structure enhances blood-brain barrier penetration